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Table 1 Difference in care received in the PROMISE-EPI intervention and control arms, Lusaka, Zambia

From: Barriers and facilitators of a large clinical trial on prevention of HIV transmission through breastfeeding in Lusaka, Zambia: a qualitative study

Intervention arm

Control arm

PROMISE-EPI prevention package

Zambian standard of care

- POC for maternal viral load monitoring at EPI-2 and M6

- Immediate single-drug (lamivudine) infant prophylaxis initiation in case of mother viral load ≥ 1000cp/ml

- Monthly visits for infants on lamivudine

Before 2020:

- Viral load monitoring every 6 months during the breastfeeding period

After 2020:

- Extended three drug infant prophylaxis (AZT/3TC + NVP) in case of maternal viral load ≥ 1000 cp/ml at 10 weeks and maternal viral load follow-up every 3 months

  1. POC point-of-care, EPI-2 second visit of the expanded program on immunization, AZT zidovudine, 3TC lamivudine, NVP nevirapine