Ó£»¨ÊÓƵ

Chung et al. [29] (2021)

RCT. Single-center

±õ—I±õ±õ

16

13

T 52.4 ± 8.9

C: 50.3 ± 7.7

AC

Aerobic exercise modality: Continuous. Time: 40 min/ sessions. Frequency: 2–3 sessions /w. Duration: 3m. Intensity:70%-75% VO₂max

Linear

(5)(22)

De Luca et al. [30] (2016)

RCT. Single-center

±õ—I±õ±õ

10

10

T: 50.2 ± 9.7

°ä:46.0 ±â¶Ä‰2.8

Chemotherapy, radiation, hormonal therapy

Aerobic exercise modality: Continuous. Time: 30 min/ sessions. Frequency: 2 sessions /w. Duration: 24w. Intensity:70%-75% HR max

Linear

(5)(12)

Lee et al. [31] (2020)

RCT. Single-center

0 to 3

48

45

T: 52.8 ± 10.6

C: 53.6 ± 10.1

Chemotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity:65%-80% HR max

Nonlinear

(7)(18)(20)(21)

Hornsby et al. [32] (2013)

RCT. Single-center

±õ±õµþ—I±õ±õ

10

10

T: 51 ± 6

C: 46 ± 11

AC, neoadjuvant chemotherapy

Aerobic exercise modality: Continuous & Interval. Time:1st w: 15–20 min/ sessions. 2nd -4th w: 30min/ sessions.5th -6th w: 30—45min/sessions. 7th -9th w: 20min/ sessions. 10th -12th w: 20min / sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 1st – 4th w: 60% VO₂max. 5th-6th w: 60%-65% VO₂max; 7th -9th w: 60%-70% VO₂max; 10th -12th w: 60%-70%VO₂max & 100%VO₂max

Nonlinear

(5)(22)

Dieli-Conwright et al. [33] (2018)

RCT. Single-center

±õ—I±õ±õ

48

45

T: 52.8 ± 10.6

C: 53.6 ± 10.1

Chemotherapy, radiotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65%-80% HR max

Nonlinear

(6)(8)(10)(11)(12)(13)(14)

Dieli-Conwright et al. [34] (2018)

RCT. Single-center

±õ—I±õ±õ

48

45

T: 52.8 ± 10.6

C: 53.6 ± 10.1

Chemotherapy, radiotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65%-80% HR max

Nonlinear

(5)

Lee et al. [35] (2019)

RCT. Single-center

±õ—I±õ±õ

48

45

T: 52.8 ± 10.6

C: 53.6 ± 10.1

Chemotherapy, radiotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65%-80% HR max

Nonlinear

(9)(19)

Cornette et al. [36] (2016)

RCT. Single-center

±õ—I±õ±õB

20

22

T: 49

C: 52

3 FEC100, 3

Aerobic exercise modality: Continuous. Time: Start with 20 min, increase by 5 min per 6 weeks. Frequency: 3 sessions /w. Duration: 27w. Intensity: 18 ± 2 maximum rated perceived exertion

Nonlinear

(5)

Ochi et al. [37] (2022)

RCT. Single-center

early-stage

21

23

Hormone therapy

Aerobic exercise modality: High Intensity Aerobic Interval. Time: NA. Frequency: 3 sessions /w. Duration: 12w. Intensity: Maximum rated perceived exertion 18 ± 2

Linear

(5)

Courneya et al. [38] (2003)

RCT. Single-center

±õ—I±õ±õA

24

28

T: 59 ± 5

C: 58 ± 6

_

Aerobic exercise modality: Continuous. Time: Start with 15 min and increase by 5 min every 3 weeks. Frequency: 3 sessions /w. Duration: 15w. Intensity: 70%—75% VO₂max

Nonlinear

(5)(6) (10)

Scott et al. [39] (a) (2020)

RCT. Single-center

±õ—I±õ±õ

58

57

T: 59 ± 9

C: 58 ± 9

Surgery, chemotherapy, radiotherapy, endocrine therapy

Aerobic exercise modality: Continuous. Time:1st-4th w:30–40 min; 5th -16th w: 40. Frequency: 1st – 3rd w: 3 sessions /w; 4th -16th w: 4 sessions /w. Duration: 16w. Intensity: 1st – 3rd w: 55%-60% VO₂max, 4th -16th w: 60%—70% VO₂max

Linear

(5)

Scott et al. [39] (b) (2020)

RCT. Single-center

±õ—I±õ±õ

59

57

T: 58 ± 9

C: 58 ± 9

Surgery, chemotherapy, radiotherapy, endocrine therapy

Aerobic exercise modality: Interval. Time: 120 min/week. Duration: 16w. Intensity: alternated between five different dose intensities (55%, 65%, 75%, 80%, and > 95%) of VO₂max

Nonlinear

(5)

Vincent et al. [40] (2020)

RCT. Single-center

±õ—I±õ±õ

55

26

-

FEC & TZB & TAX

Aerobic exercise modality: Continuous. Time: 30 min/week. Frequency: 2 sessions /w. Duration: 6m. Intensity: 60%—70% VO_2peak

Linear

(5)(6)(11)

Hojan et al. [41] (2020)

RCT. Single-center

±õµþ—I±õ±õ´¡

26

21

T: 54.44 ± 6.29

C: 54.64 ± 5.26

TZB

Aerobic exercise modality: Continuous. Time: 45–50 min/week. Frequency: 5 sessions /w. Duration: 9w. Intensity: 80% HR max

Linear

(21)(22)

Murtezani et al. [42] (2014)

RCT. Single-center

±õ—I±õ±õA

30

32

T: 53 ± 11

C: 51 ± 11

Surgery

Aerobic exercise modality: Continuous. Time: Start with 15 min, increase by 2 min per week. Frequency: 3 sessions /w. Duration: 10 w. Intensity: 50% -75%HRR

Nonlinear

(6)(10)

Lee et al. [35] (2019)

RCT. Single-center

±õ—I±õ±õ

15

15

T: 47.1 ± 7.9

C: 44.7 ± 11.2

AC

Aerobic exercise modality: High Intensity Aerobic Interval. Time: 20 min. Frequency: 3 sessions /w. Duration: 8 w. Intensity: 7 times of a 1- min interval performed at 90% PPO; followed by a 2 – min interval performed at 10% PPO

Linear

(5)

Courneya et al. [43] (2007)

RCT. Single-center

±õ—I±õ±õA

71

73

T: 49

C: 49

AC & TAX & FEC100C, CE120F

Aerobic exercise modality: Continuous. Time: Start with 15 min and increase by 5 min every 3 weeks. Frequency: 3 sessions /w. Duration: 8 w. Intensity: 60% -80% VO₂max

Nonlinear

(5)(10)(11) (12)(13)

Jones et al. [44] (2013)

RCT. Single-center

±õ±õµþ—I±õ±õC

10

10

T: 51 ± 6

C: 46 ± 11

AC

Aerobic exercise modality: Continuous & Interva. Time: 1st w: 15–20 min/ sessions. 2nd -4th w: 30min/ sessions. 5th -6th w: 30-45min/ sessions. 7th -9th w: 20min/ sessions. 10th -12th w: 20min / sessions. Frequency: 3 sessions /w. Duration: 12 w. Intensity: 1st – 4th w: 60% VO₂max. 5th-6th w: 60%-65%VO₂max. 7th -9th w: 60%-70%VO₂amx. 10th -12th w: 60%-70%VO₂max & 100%VO₂max

Nonlinear

(5)

Irwin et al. [45] (2009)

RCT. Single-center

±õ—I±õ±õA

37

38

T: 56.5 ± 9.5

C: 55.1 ± 7.7

Radiation and chemotherapy

Aerobic exercise modality: Continuous. Time: 15–30 min/ sessions. Frequency: 3 sessions /w. Duration: 6m. Intensity: 50% increased to 60%-80% HRmax

Nonlinear

(6)(10)(12)(13)(14)(15)

Northey et al. [46] (a) (2019)

RCT. Single-center

±õ—I±õ±õ

5

6

T: 67.8 ± 7.0

C: 61.5 ± 7.8

Surgery, chemotherapy, radiation. Aromatase inhibitor

Aerobic exercise modality: Continuous. Time: 20 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 55—65%³Õ°¿₂max

Linear

(5)

Northey et al. [46] (b) (2019)

RCT. Single-center

±õ—I±õ±õ

6

6

T: 60.3 ± 8.1

C: 61.5 ± 7.8

Surgery. Radiation. Aromatase inhibitor

Aerobic exercise modality: High Intensity Aerobic Interval. Time: 20 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 4 intervals in 1st w, increased by one each week until the target of 7 intervals was achieved in 4th w 50—90% VO₂max

Nonlinear

(5)

Fairey et al. [47] (2005)

RCT. Single-center

±õ—I±õ±õA

24

28

T: 59 ± 5

C: 58 ± 6

Surgery, radiation, chemotherapy

Aerobic exercise modality: Continuous. Time: 15min for weeks 1 through 3, and then systematically increased by 5min every three weeks thereafter to 35 min for weeks 13 through 15. Frequency: 3 sessions /w. Duration: 15w. Intensity: 70—75% VO₂max

Nonlinear

(17)(18)(19)(20)(21)

Irwin et al. [48] (2015)

RCT. Single-center

0—I±õ±õ

45

38

T: 62 ± 7.0

C: 60.5 ± 7.0

Radiation, chemotherapy

Aerobic exercise modality: Continuous. Time: 150 min/w. Frequency: 2 sessions /w. Duration: 12m Intensity: started at 50% of HRmax and increased over the 1st month to 60% to 80% of HRmax

Linear

(5)

de Paulo et al. [49] (2018)

RCT. Single-center

±õ—I±õ±õ

18

18

T: 63.2 ± 7.1

C: 66.6 ± 9.6

Aromatase inhibitor therapy

Aerobic exercise modality: Continuous. Time: 1-2nd week: 20min. 3-36th week: 30min. Frequency: 3 sessions /w. Duration: 36w. Intensity: 1-2nd w: 50–60% HRmax. 3-10th w: 60–65% HRmax. 11-18th w: 65–70% HRmax. 19-28th w: 70–75% HRmax. 20-36th w: 75–80% HRmax

Linear

(10)(11)(12)(13)(17)(19)(20)(21)

Møller et al. [50] (a) (2015)

RCT. Single-center

±õ—I±õ±õ

9

10

°Õ:57.17 ±â¶Ä‰10.51

C: 46.95 ± 9.19

AC & TAX & CYC

Aerobic exercise modality: Continuous & Interval. Time: 60–90 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 95–95% HRmax

Nonlinear

(5)(6)(11)(12)(13)

Møller et al. [50] (b) (2015)

RCT. Single-center

±õ—I±õ±õ

10

10

T: 48.49 ± 8.41

°ä:46.95 ±â¶Ä‰9.19

AC & TAX & CYC

Aerobic exercise modality: Continuous. Time: 30 min/ sessions. Frequency: 5 sessions /w. Duration: 12w. Intensity: 70–75% HRmax

Linear

(5)(6)(11)(12)(13)

Ma et al. [51] (2018)

RCT. Single-center

-

31

33

T: 44 ± 6

C: 44 ± 6

AC

Aerobic exercise modality: Interval. Time: 50 min/ sessions. Frequency: 3 sessions/w. Duration: 16w. Intensity: Work: 90 -95% HRmax. Rest: 50 –70% HRmax

Linear

(5)(22)

Al-Majid et al. [52] (2015)

RCT. Single-center

±õ—I±õ

6

7

T: 52.7 ± 10.7

C: 47.9 ± 10.4

Adjuvant chemotherapy

Aerobic exercise modality: Continuous. Time: 20–40 min/ sessions. Frequency: 1st w: 2 sessions, 2nd-12th w: 3 sessions/w. Duration: 12w. Intensity: 1st w: 40%—50% HRR. 2nd-3rd w: 50%—70% HRR. 4th -12^thw: 70%—80% HRR

Nonlinear

(5)

Jones et al. [53] (2013)

RCT. Single-center

0 to IIIA

36

31

T: 56.4 ± 9.6

C: 55.4 ± 7.6

Adjuvant chemotherapy

Aerobic exercise modality: Continuous. Time: 15min for week 1, and then gradually increased minutes of exercise per week to 30 min for weeks 5 through 12. Frequency: 5 sessions/w. Duration: 6m. Intensity: started at 50% HRmax to 60%—80% HRmax

Nonlinear

(21)

Rogers et al. [54] (2009)

RCT. Single-center

I, II, or IIIA

20

19

T: 52 ± 15

C: 54 ± 8

Aromatase inhibitors or selective estrogen receptor modulators

Aerobic exercise modality: Continuous. Time: 40 – 45 min / sessions. Frequency: 1st -2nd week: 3 sessions/w. 3rd-6th week: 4 sessions/w. 7th -12th week: 5 sessions/w. Duration: 12w. Intensity: moderate intensity

Nonlinear

(6)(12)(16)

Dieli-Conwright et al. [55] (a) (2021)

RCT. Single-center

±õ—I±õ±õ; Hispanic ethnicity

28

24

T: 46.9 ± 10.2

C: 46.7 ± 10

Surgery, radiation, chemotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min of aerobic exercise per session by 16th w. Frequency: 3 sessions/w. Duration: 16w. Intensity: 65%-80% HR max

Nonlinear

(5)

Dieli-Conwright et al. [55] (b) (2021)

RCT. Single-center

±õ—I±õ±õ; Non-Hispanic ethnicity

19

22

T: 55.6 ± 10.5

C: 55.9 ± 10.3

Surgery, radiation, chemotherapy

Aerobic exercise modality: Continuous. Time: 5 min every 3–4 weeks resulting in a total of 45 min of aerobic exercise per session by 16th w. Frequency: 3 sessions/w. Duration: 16w. Intensity: 65%-80% HR max

Nonlinear

(5)

Nuri et al. [56] (2012)

RCT. Single-center

I to IIIB

14

15

T: 58.27 ± 6.31

C: 58.27 ± 6.31

Hormone therapy

Aerobic exercise modality: Continuous. Time: Start with 25 min and increase by 10 min every 5 weeks. Frequency: 2 sessions/w. Duration: 15w. Intensity: 45%-65% HR max

Nonlinear

(5)(6)(10)(14)(15)(16)(17)(20)

Lahart et al. [57] (2018)

RCT. Single-center

±õ—I±õ±õ

16

16

T: 52.5 ± 10.7

C: 52 ± 8.6

_

Aerobic exercise modality: Continuous. Time: 1st -3rd month: 30 min/sessions. 4th-6th month: > 30 min/sessions. Frequency: 1st -3rd m: 3–5 sessions /w. 4th-6th m: 5–7 sessions /w. Duration: 24w. Intensity: Moderate -vigorous

Nonlinear

(5)

Rogers et al. [58] (2013)

RCT. Single-center

I, II or IIIA

11

9

T: 58 ± 6.1

C: 53.7 ± 13.9

_

Aerobic exercise modality: Continuous. Time: 150 min/w. Duration: 12w. Intensity: Moderate intensity

Linear

(5)(6)(12) (16)

Guinan et al. [59] (2013)

RCT. Single-center

±õ—I±õ±õ

16

10

T: 50.05 ± 8.27

C: 45.05 ± 9.04

Adjuvant hormone therapy and anti-Her2 directed therapy

Aerobic exercise modality: Continuous. Time: 21-42min /sessions. Frequency: 21-42min /sessions. Duration: 8w. Intensity: 30%—75% HRR

Nonlinear

(15)(17)(18)(19)(20)

Herrero et al. [60] (2011)

RCT. Single-center

±õ—I±õ

8

8

T: 50.05 ± 8.27

°ä:45.05 ±â¶Ä‰9.04

CFM

Aerobic exercise modality: Continuous. Time: Gradually increased from 20 to 30min per session. Frequency: 2 sessions /w. Duration: 8w. Intensity: Gradually increased from 30 to 75% HRR

Nonlinear

(5)(10)(11)(12)

Ligibel et al. [61] (2008)

RCT. Single-center

±õ—I±õ±õ

42

40

T: 52 ± 9

°ä:53 ±â¶Ä‰9

chemotherapy and/or radiation therapy

Aerobic exercise modality: Continuous. Time: 90 min / sessions. Frequency: 2 sessions /w. Duration: 16w. Intensity: Moderate intensity

Linear

(6)(10)(12)(14)(15)(16)

Lahart et al. [62] (2016)

RCT. Single-center

±õ—I±õ±õ

40

40

T: 52.4 ± 10.3

C: 54.7 ± 8.3

Radiation therapy and/or chemotherapy

Aerobic exercise modality: Continuous. Time: 30 min / sessions. Frequency: 5 sessions /w. Duration: 12w. Intensity: Moderate intensity

Linear

(6)(10)(12)(17)(18)(19)(20)

DeNysschen et al. [63] (2010)

RCT. Single-center

±õ—I±õ±õ

36

30

T: 48.7 ± 8.4

C: 49.5 ± 9.5

Chemotherapy

Aerobic exercise modality: Continuous. Time: 20–30 min / sessions. Frequency: 3–5 sessions /w. Duration: 4-6m. Intensity: 60–80% VO₂peak

Nonlinear

(10)(12)(13)

Kim et al. [27] (a) (2021)

Cohort trial. Single-center

-

11,154

7410

T: 50.9 ± 9.6

C: 53.1 ± 10.1

Radiotherapy,Ìýcardiotoxic chemotherapy,Ìýaromatase inhibitor, Tamoxifen

Aerobic exercise modality: Continuous. Time: 1–499 MET-mins/week. Duration: 5 year. Intensity: Low

Linear

(1)(2)(3)

Kim et al. [27] (b) (2021)

11,110

7410

T: 50.9 ± 9.4

C: 53.1 ± 10.1

Aerobic exercise modality: Continuous. Time: 1–499 MET-mins/week. Duration: 5 year. Intensity: Medium

Linear

(1)(2)(3)

Kim et al. [27] (c) (2021)

10,101

7410

T: 50.6 ± 8.4

C: 53.1 ± 10.1

Aerobic exercise modality: Continuous. Time: 1–499 MET-mins/week. Duration: 5 year. Intensity: High

Linear

(1)(2)(3)

Jones et al. [28] (a) (2016)

Cohort trial. Single-center

±õ—I±õ±õ

747

741

T: 56.6 ± 10.5

C: 58.7 ± 10.4

Surgery, chemotherapy, radiotherapy, tamoxifen or aromatase inhibitor

Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 5.4 MET-h/week

Linear

(1)(2)(4)

Jones et al. [28] (b) (2016)

741

741

T: 57.2 ± 10.3

C: 58.7 ± 10.4

Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 16.3 MET-h/week

Linear

(1)(2)(4)

Jones et al. [28] (c) (2016)

744

741

T: 55.4 ± 10.5

C: 58.7 ± 10.4

Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 40 MET-h/week

Linear

(1)(2)(4)