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Table 2 Characteristics of selected studies

From: Air pollution: a latent key driving force of dementia

First Author

Title

study design

Country (city)

N

Walter A. Kukull

(1995) [29]

Solvent Exposure as a Risk Factor for Alzheimer's Disease: A Case Control Study

°ä²¹²õ±ð–C´Ç²Ô³Ù°ù´Ç±ô

USA

(Seattle)

Case: 193

Control: 243

Total: 436

Ulrich Ranft

(2009) [41]

Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly

Cohort

Germany

(Ruhr)

402

Kuang-Hsi Chang

(2014) [42]

Increased Risk of Dementia in Patients Exposed to Nitrogen Dioxide and Carbon Monoxide: A Population-Based Retrospective Cohort Study

Cohort

Taiwan

(Taichung)

29,547

Yun-Chun Wu

(2015) [30]

Association between air pollutants and dementia risk in the elderly

°ä²¹²õ±ð–c´Ç²Ô³Ù°ù´Ç±ô

Taiwan

(Taipei)

Case: 374

Control: 497

Total: 871

Chau-Ren Jung

(2015) [43]

Ozone, Particulate Matter, and Newly Diagnosed Alzheimer’s Disease: A Population-Based Cohort Study in Taiwan

Cohort

Taiwan

(National)

95,690

Anna Oudin

(2016) [44]

Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden: A Longitudinal Study

Cohort

Sweden

(±«³¾±ðÃ¥)

1,806

Hong Chen

(2017) [45]

Exposure to ambient air pollution and the incidence of dementia: A population-based cohort study

Cohort

Canada

(Ontario)

2,066,639

Dante Roger Culqui

(2017) [46]

Association between environmental factors and emergency hospital admissions due to Alzheimer's disease in Madrid

Cohort

Spain

(Madrid)

3,287

Jiu-Chiuan Chen

(2017) [47]

Particulate Air Pollutants, Brain Structure, and Neurocognitive Disorders in Older Women

Cohort

USA

(National)

1,403

John Andersson

(2018) [48)

Road traffic noise, air pollution, and risk of dementia – results from the Betula project

Cohort

Sweden

(±«³¾±ðÃ¥)

1,721

Anna Oudin

(2018) [49]

Association between air pollution from residential wood burning and dementia incidence in a longitudinal study in Northern Sweden

Cohort

Sweden

(±«³¾±ðÃ¥)

1,806

Iain M Carey

(2018) [21]

Are noise and air pollution related to the incidence of dementia? A cohort study in London, England

Cohort

England

(London)

130,978

Chung-Yi Li

(2019) [31]

Association between air pollution and risk of vascular dementia: A multipollutant analysis in Taiwan

°ä²¹²õ±ð–c´Ç²Ô³Ù°ù´Ç±ô

Taiwan

(National)

Case: 831

Control: 3,324

Total: 4,155

Hyewon Lee

(2019) [50]

Exposure to ambient fine particles and neuropsychiatric symptoms in cognitive disorder: A repeated measure analysis from the CREDOS (Clinical Research Center for Dementia of South Korea) study

Cohort

Republic of Korea

(Seoul)

645

Ruo-Ling Li

(2019) [51]

Influence of PM2.5 Exposure Level on the Association between Alzheimer’s Disease and Allergic Rhinitis: A National Population-Based Cohort Study

Cohort

Taiwan

(National)

2,384

Francesco Cerza

(2019) [52]

Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study

Cohort

Italy

(Rome)

350,844

Anna Oudin

(2019) [53]

Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE 4 in the Betula Cohort

Cohort

Sweden

(Umea)

1,567

Han-Wei Zhang

(2019) [54]

Long-Term Exposure to Ambient Hydrocarbons Increases Dementia Risk in People Aged 50 Years and above in Taiwan

Cohort

Taiwan

(National)

178,085

Marta Crous-Bou

(2020) [1]

Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer’s dementia

Cohort

Spain

(Barcelona)

958

Liuhua Shi

(2020) [2]

Long-term effects of PM2.5 on neurological disorders in the American Medicare population: a longitudinal cohort study

Cohort

USA

(National)

63,038,019

Audrey Smargiassi

(2020) [55]

Exposure to ambient air pollutants and the onset of dementia in Quebec, Canada

Cohort

Canada

(Quebec)

1,807,133

Sindana D Ilango

(2020) [56]

The role of cardiovascular disease in the relationship between air pollution and incident dementia: a population-based cohort study

Cohort

Canada

(Ontario)

34,391

Kimberly C. Paul

(2020) [57]

Traffic-Related Air Pollution and Incident Dementia: Direct and Indirect Pathways Through Metabolic Dysfunction

Cohort

USA

(National)

1,564

Weiran Yuchi

(2020) [32]

Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study

°ä²¹²õ±ð–c´Ç²Ô³Ù°ù´Ç±ô

Canada

(Metro Vancouver)

678,000

Marion Mortamais

(2021) [22]

Long-term exposure to ambient air pollution and risk of dementia: Results of the prospective Three-City Study

Cohort

France

(Dijon, Bordeaux, and Montpellier)

7,066

Jiping Tan

(2021) [35]

Associations of particulate matter with dementia and mild cognitive impairment in China: A multicenter cross-sectional study

Cross-sectional

China

(National)

7,040

Jinjun Ran

(2021) [58]

Long-term exposure to fine particulate matter and dementia incidence: A cohort study in Hong Kong

Cohort

Hong Kong

59,349

Andrew J. Petkus

(2021) [36]

Associations Between Air Pollution Exposure and Empirically Derived Profiles of Cognitive Performance in Older Women

Cross-sectional

USA

2,142

Rachel M.Shaffer

(2021) [59]

Fine Particulate Matte rand Dementia Incidence in the Adult Changes in Thought Study

Cohort

USA

(Seattle)

4,166

Sung Han Rhew

(2021) [33]

Exposure to low-dose ambient fine particulate matter PM2.5 and Alzheimer’s disease, non-Alzheimer’s dementia, and Parkinson’s disease in North Carolina

°ä²¹²õ±ð–c´Ç²Ô³Ù°ù´Ç±ô

USA

(North Carolina)

Case: 1,665,073

Control: 357,574

Total: 2,022,647

Diana Younan

(2021) [60]

PM2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women

Cohort

USA

(48 states)

1,365

Maayan Yitshak-Sade

(2021) [61]

PM2.5 and Hospital Admissions Among Medicare Enrollees with Chronic Debilitating Brain Disorders

Cohort

USA

(National)

30,079,287

Rachel M. Shaffer

(2021) [62]

Fine Particulate Matter and Markers of Alzheimer’s Disease Neuropathology at Autopsy in a Community-Based Cohort

Cohort

USA

(National)

5,546

Kevin J Sullivan

(2021) [63]

Ambient Fine Particulate Matter (PM2.5) Exposure and Incident Mild Cognitive Impairment and Dementia

Cohort

USA

(National)

2,735

Hedi Katre Kriit

(2021) [64]

Annual dementia incidence and monetary burden attributable to fine particulate matter (PM2.5) exposure in Sweden

Cohort

Sweden

(National)

820

Liuhua Shi

(2021) [65]

A national cohort study (2000–2018) of long-term air pollution exposure and incident dementia in older adults in the United States

Cohort

USA

(National)

24,689,818

Feng Cheng Lin

(2021) [34]

Air Pollution Is Associated with Cognitive Deterioration of Alzheimer’s Disease

°ä²¹²õ±ð–c´Ç²Ô³Ù°ù´Ç±ô

Taiwan

(Kaohsiung,Pingtung)

704

Jing Wu

(2022) [66]

Air pollution as a risk factor for Cognitive Impairment no Dementia (CIND) and its progression to dementia: A longitudinal study

Cohort

Sweden

(Stockholm)

1,987

Zorana J. Andersen

(2022) [67]

Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study

Cohort

Sweden, Denmark, France, Netherlands, Germany, Austria

271,720

ErinO. Semmens

(2022) [37]

Air pollution and dementia in older adults in the Ginkgo Evaluation of Memory Study

Cross-sectional

USA

(Winston, Hagerstown, Sacramento, Pittsburgh)

2,564

Lilian Calderón-Garcidueñas

(2022) [38]

Metals, Nanoparticles, Particulate Matter, and Cognitive Decline

Cross-sectional

Mexico

(Mexico City)

336

Diana Younan

(2022) [68]

Racial/Ethnic Disparities in Alzheimer’s Disease Risk: Role of Exposure to Ambient Fine Particles

Cohort

USA

(24 states)

6485

Fan He

(2022) [69]

Impact of air pollution exposure on the risk of Alzheimer’s disease in China: A community-based cohort study

Cohort

China

(Changshan, Haishu, Jingning, Tongxiang, Yuecheng, Yuhuan)

6,115

Dylan Wood

(2022) [70]

Exposure to Ambient Air Pollution and the Incidence of Dementia in the Elderly of England: The ELSA Cohort

Cohort

UK

(National)

8,525

Lilian Calderón-Garcidueñas

(2022) [39]

Hemispheric Cortical, Cerebellar and Caudate Atrophy Associated to Cognitive Impairment in Metropolitan Mexico City Young Adults Exposed to Fine Particulate Matter Air Pollution

Cross-sectional

Mexico

(Mexico City)

302

Cheng Chen

(2022) [71]

B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women’s Health Initiative Memory Study

Cohort

USA

(National)

7,183

Noémie Letellier

(2022) [72]

Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g computation

Cohort

France

(Bordeaux, Dijon, and

Montpellier)

7,051

Zhenjiang Li

(2022) [19]

Neighborhood characteristics as confounders and effect modifiers for the association between air pollution exposure and subjective cognitive functioning

Cross-sectional

USA

(Atlanta)

12,058

Kimberly L. Parra

(2022) [73]

Exposure to air pollution and risk of incident dementia in the UK Biobank

Cohort

UK

(National)

187,194

Michelle L. Trevenen

(2022) [74]

Ambient air pollution and risk of incident dementia in older men living in a region with relatively low concentrations of pollutants: The Health in Men Study

Cohort

Australia

(Perth)

11,243

Daniel Mork

(2023) [18]

Time-lagged relationships between a decade of air pollution exposure and first hospitalization with Alzheimer’s disease and related dementias

Cohort

USA

(National)

8,507,437

Liuhua Shi

(2023) [75]

Incident dementia and long-term exposure to constituents of fine particle air pollution: A national cohort study in the United States

Cohort

USA

(National)

37.7 million

Haisu Zhang

(2023) [40]

Short-term associations between ambient air pollution and emergency department visits for Alzheimer’s disease and related dementias

Cross-sectional

USA

(California, Missouri, North Carolina, New Jersey, and New York)

1,595,783