樱花视频

Skip to main content

Table 3 RERI and AP for additive interaction between BMI categories and genetic riska

From: Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank

BMI categories

Genetic Riskb

Intermediate

High

P for overall test

RERIc(95%CI)

APc(95%CI)

RERIc(95%CI)

APc(95%CI)

RERI

AP

HTN

鈥僌verweight (25.0鈥�29.9聽kg/m2)

0.07 (0.02鈥�0.13)

0.04 (0.01鈥�0.07)

0.22 (0.16鈥�0.28)

0.09 (0.07鈥�0.12)

鈥�&濒迟;鈥�0.001

鈥�&濒迟;鈥�0.001

鈥僌besity (鈮モ��30.0聽kg/m2)

0.27 (0.18鈥�0.36)

0.08 (0.05鈥�0.11)

0.53 (0.43鈥�0.62)

0.13 (0.11鈥�0.16)

AF

鈥僌verweight (25.0鈥�29.9聽kg/m2)

0.02 (-0.09鈥�0.13)

0.01 (-0.06鈥�0.08)

0.19 (0.07鈥�0.31)

0.08 (0.03鈥�0.13)

鈥�&濒迟;鈥�0.001

鈥�&濒迟;鈥�0.001

鈥僌besity (鈮モ��30.0聽kg/m2)

0.28 (0.13鈥�0.42)

0.10 (0.05鈥�0.16)

0.67 (0.51鈥�0.83)

0.19 (0.14鈥�0.23)

CHD

鈥僌verweight (25.0鈥�29.9聽kg/m2)

0.03 (-0.06鈥�0.12)

0.02 (-0.04鈥�0.08)

0.16 (0.07鈥�0.26)

0.08 (0.03鈥�0.13)

鈥�&濒迟;鈥�0.001

鈥�&濒迟;鈥�0.001

鈥僌besity (鈮モ��30.0聽kg/m2)

0.04 (-0.08鈥�0.16)

0.02 (-0.04鈥�0.07)

0.37 (0.25鈥�0.49)

0.13 (0.09鈥�0.18)

Stroke

鈥僌verweight (25.0鈥�29.9聽kg/m2)

0.06 (-0.06鈥�0.18)

0.05 (-0.05鈥�0.15)

0.08 (-0.04鈥�0.21)

0.07 (-0.03鈥�0.17)

0.347

0.368

鈥僌besity (鈮モ��30.0聽kg/m2)

-0.04 (-0.19鈥�0.11)

-0.03 (-0.15鈥�0.08)

0.07 (-0.08鈥�0.21)

0.05 (-0.06鈥�0.15)

HF

鈥僌verweight (25.0鈥�29.9聽kg/m2)

-0.01 (-0.14鈥�0.12)

-0.01 (-0.11鈥�0.10)

0.16 (0.03鈥�0.29)

0.11 (0.02鈥�0.20)

0.073

0.072

鈥僌besity (鈮モ��30.0聽kg/m2)

0.05 (-0.14鈥�0.23)

0.02 (-0.06鈥�0.09)

0.12 (-0.07鈥�0.30)

0.05 (-0.03鈥�0.12)

  1. Abbreviations: AF鈥塧trial fibrillation, AP鈥塼he attributable proportion due to interaction, BMI鈥塨ody mass index, CHD鈥塩oronary heart disease, CI鈥塩onfidence interval, HF鈥塰eart failure, HTN鈥塰测辫别谤迟别苍蝉颈辞苍, PRS鈥塸olygenic risk score, RERI鈥塼he relative excess risk due to interaction
  2. aAdjusted for age, sex, ethnicity, education, employment status, household income, smoking status, drink frequency, healthy diet, IPAQ, Townsend deprivation index, the top two pollution principal components, and the top four principal components of ancestry and genotyping batch. bDefined by polygenic risk score; low (lowest tertiles), intermediate (second tertiles) and high (highest tertiles). cTo estimate RERI and AP, the normal weight (<鈥�25.0聽kg/m2) and the lowest genetic risk groups were the reference categories
Back to article page

樱花视频

ISSN: 1471-2458

Contact us