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Table 2 Associations of the risk for incident cardiovascular disease and BMI categories

From: Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank

BMI categories

Number of Cases/

Person-Years

Model 1a

Model 2b

HR(95%CI)

P Value

P for trend

HR(95%CI)

P Value

P for trend

HTN

 Normal weight (< 25.0 kg/m2)

21,971/1,784,016

1.00 [Reference]

NA

 &±ô³Ù; 0.001

1.00 [Reference]

NA

 &±ô³Ù; 0.001

 Overweight (25.0–29.9 kg/m2)

45,356/2,047,075

1.64 (1.61–1.66)

 &±ô³Ù; 0.001

1.60 (1.57–1.63)

 &±ô³Ù; 0.001

 Obesity (≥ 30.0 kg/m2)

35,739/971,060

2.87 (2.82–2.92)

 &±ô³Ù; 0.001

2.68 (2.63–2.73)

 &±ô³Ù; 0.001

AF

 Normal weight (< 25.0 kg/m2)

6069/1,959,531

1.00 [Reference]

NA

 &±ô³Ù; 0.001

1.00 [Reference]

NA

 &±ô³Ù; 0.001

 Overweight (25.0–29.9 kg/m2)

11,170/2,480,821

1.19 (1.16–1.23)

 &±ô³Ù; 0.001

1.18 (1.14–1.22)

 &±ô³Ù; 0.001

 Obesity (≥ 30.0 kg/m2)

9558/1,390,484

1.96 (1.90–2.02)

 &±ô³Ù; 0.001

1.86 (1.80–1.92)

 &±ô³Ù; 0.001

CHD

 Normal weight (< 25.0 kg/m2)

7357/1,918,358

1.00 [Reference]

NA

 &±ô³Ù; 0.001

1.00 [Reference]

NA

 &±ô³Ù; 0.001

 Overweight (25.0–29.9 kg/m2)

14,612/2,362,781

1.35 (1.31–1.39)

 &±ô³Ù; 0.001

1.32 (1.29–1.36)

 &±ô³Ù; 0.001

 Obesity (≥ 30.0 kg/m2)

10,783/1,290,768

1.95 (1.90–2.01)

 &±ô³Ù; 0.001

1.79 (1.73–1.84)

 &±ô³Ù; 0.001

Stroke

 Normal weight (< 25.0 kg/m2)

2934/1,977,315

1.00 [Reference]

NA

 &±ô³Ù; 0.001

1.00 [Reference]

NA

 &±ô³Ù; 0.001

 Overweight (25.0–29.9 kg/m2)

4752/2,517,611

1.09 (1.04–1.14)

 &±ô³Ù; 0.001

1.07 (1.02–1.12)

0.004

 Obesity (≥ 30.0 kg/m2)

3243/1,423,950

1.38 (1.31–1.45)

 &±ô³Ù; 0.001

1.27 (1.21–1.34)

 &±ô³Ù; 0.001

HF

 Normal weight (< 25.0 kg/m2)

2641/1,995,755

1.00 [Reference]

NA

 &±ô³Ù; 0.001

1.00 [Reference]

NA

 &±ô³Ù; 0.001

 Overweight (25.0–29.9 kg/m2)

5245/2,546,229

1.27 (1.21–1.33)

 &±ô³Ù; 0.001

1.22 (1.17–1.28)

 &±ô³Ù; 0.001

 Obesity (≥ 30.0 kg/m2)

5776/1,435,178

2.66 (2.54–2.79)

 &±ô³Ù; 0.001

2.27 (2.16–2.38)

 &±ô³Ù; 0.001

  1. Abbreviations: AF atrial fibrillation, BMI body mass index, CHD coronary heart disease, CI confidence interval, HF heart failure, HR hazard ratio, HTN h²â±è±ð°ù³Ù±ð²Ô²õ¾±´Ç²Ô, NA not applicable
  2. aModel 1: age and sex. bModel 2: Model 1 + ethnicity, education, employment status, household income, smoking status, drink frequency, healthy diet, IPAQ, Townsend deprivation index, and the top two pollution principal components