Table 3 Application of standardized rules for choice of final outcome to estimate effect of calcium supplementation during pregnancy on neonatal mortality
Outcome measure | Studies | Total Events | Reduction (Relative risk) | GRADE quality of pooled estimate | Application of standard rules |
|---|---|---|---|---|---|
All-cause neonatal mortality | 1 | 90 | 30 % (RR 0.56-0.88) | Moderate (鈫� low) | Rule 1: applies 鈥�If there is no evidence of effect on cause-specific mortality, And there is evidence of effect on all-cause mortality鈥� Then translate all-cause into cause-specific, and downgrade the quality score by one level鈥漑47] |
Preterm Birth | 5 | 967 | 12% (RR 0.88; 95% CI 0.78, 0.99) | High | 听 |
Low birth weight (< 2500 g) | 3 | 1159 | 19 % (RR 0.81; 95 % CI 0.58-1.12] | Moderate | 听 |
Small for gestational age | 2 | 84 | 10 % (RR 0.90; 95 % CI 0.59-1.38) | Moderate | 听 |