Table 4
| 听 | 听 | Quality Assessment | Summary of Findings | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 听 | 听 | 听 | 听 | 听 | Generalisability | 听 | Intervention | Control | 听 | |||
No of studies (ref) | Intervention | Design | Limitations | Consistency | To population of interest | To intervention of interest | GRADE of evidence | No. events | No. births | No. events | No. births | Effect size (95% CI) |
Neonatal Mortality (Tetanus Deaths): | 听 | |||||||||||
No studies identified | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | 听 | |||
Neonatal Mortality (Sepsis Deaths): | 听 | |||||||||||
3 (67, 68, 70) | Chlorhexidine vaginal and baby wipes | 1 RCT, 2 Before and after | Hospital based studies | Heterogeneity | S.Africa, Malawi, Egypt | Yes | Moderate | 21 | 10108 | 55 | 9612 | 听 |
1 (73) | Chlorhexidine to cord (day 1) | cRCT 藝 | Single study | 听 | Nepal | Yes | Moderate | 听 | 3134 | 听 | 3179 | RR = 0.69 (0.40 - 1.18) |
Neonatal Mortality (All Cause): | 听 | |||||||||||
1 (73) | Chlorhexidine to cord | cRCT | Single study | 听 | Nepal | Yes | Moderate | 72 | 4924 | 98 | 5082 | RR = 0.78 (0.57 - 1.07)* |
1 (73) | Chlorhexidine to cord (day 1) | cRCT 藝 | Single study | 听 | Nepal | Yes | Moderate | 45 | 3134 | 69 | 3179 | RR = 0.66 (0.46 - 0.95) |
1 (72) | Chlorhexidine wipes to baby | cRCT | Single study | 听 | Nepal | Yes | Moderate | 264 | 860 | 263 | 8880 | RR = 1.04 (0.87 - 1.24) |
1 (72) | Chlorhexidine wipes to baby | 肠搁颁罢艺 | Single study | 听 | Nepal | Low birth weight babies only | Moderate | 83 | 2448 | 117 | 2491 | RR = 0.72 (0.55 - 0.95) |
1 (71) | Chlorhexidine vaginal and baby wipes | 1 RCT | Single study | 听 | Pakistan | Yes | Moderate | 55 | 2505 | 56 | 2503 | RR = 0.98 (0.68 - 1.41) |
Neonatal Sepsis incidence: | 听 | |||||||||||
2 (70,71) | Chlorhexidine vaginal and baby wipes | 2 RCT | Hospital based studies | Consistent | S. Africa, Pakistan | Yes | Moderate | 179 | 6,577 | 188 | 6,560 | RR = 0.95^ (0.76 - 1.14) |
Cord infection/oomphalitis | 听 | |||||||||||
1 (73) | Chlorhexidine to cord | cRCT | Single study | 听 | Nepal | Yes | Moderate | 438 | 4703 | 638 | 4859 | RR = 0.68** (0.58 - 0.80) |